Change is possible with individualized dosing
XWYAV is a liquid taken twice or once nightly.
XYWAV dosing can be individualized for adults with Idiopathic Hypersomnia (IH)
Finding the right dose takes time
When you start taking XYWAV, your doctor may adjust or titrate your dosage each week until you reach a dose that works best for you. During this time, it’s not uncommon to experience some side effects. Make sure you tell your doctor.
Some ways your doctor can tailor your XYWAV treatment include adjusting:
Your total nightly dose
Your doctor may adjust your dose to find what nightly dosage works best for you.
The timing between your first and second dose if taken 2x nightly
Your total nightly dose
How much medicine you take if you dose once nightly, or how much medicine you take with your first and second dose if taken 2x nightly:
Once nightly (at bedtime)
Recommended starting dose: 3 g/night
Recommended maximum dose: 6 g/night
Dosing increments: 0.25 g - 1.5 g per night per week
Twice nightly (at bedtime and 2.5 to 4 hours later)
Recommended starting dose: 4.5 g divided into 2 doses
Recommended maximum dose: 9 g divided into 2 doses
Dosing increments: 0.25 g–1.5 g per night per week
Instructions for proper preparation and dosing of XYWAV
When you get your first shipment of XYWAV, be sure to read the Instructions for Use (IFU). You’ll also receive the XYWAV and XYREM® (sodium oxybate) oral solution REMS Patient Quick Start Guide along with your medication and detailed preparation and dosing instructions.
Here's an overview of what you'll need to know to take XYWAV:
Taking XYWAV once at bedtime
Before bedtime
Before bedtime
- Prepare your dose and put it in a safe and secure place
- Before you take XYWAV, your dose should be mixed with approximately ¼ cup of water in the empty pharmacy containers provided for you
At bedtime
At bedtime
- Take your dose while in bed and lie down immediately
- XYWAV can cause sleep very quickly without making you feel drowsy
- Some people fall asleep within 5 minutes, and most fall asleep within 15 minutes (though the time it takes any individual to fall asleep may vary from night to night)
Taking XYWAV twice nightly
Before bedtime
Before bedtime
- Prepare both of your doses and put them in a safe and secure place
- Before you take XYWAV, your doses should be mixed with approximately ¼ cup of water per dose in the empty pharmacy containers provided for you
At bedtime
At bedtime
- Take your first dose while in bed and lie down immediately
- XYWAV can cause sleep very quickly without making you feel drowsy
- Some people fall asleep within 5 minutes, and most fall asleep within 15 minutes (though the time it takes any individual to fall asleep may vary from night to night)
2.5 to 4 hours (after bedtime)
2.5 to 4 hours (after bedtime)
- You must wake up to take the second dose 2.5 to 4 hours after your first, as instructed by your doctor
- You may want to set an alarm clock to make sure you wake up to take the second dose
- If you are prescribed XYWAV twice nightly and miss the second dose, skip it
- Never take 2 doses of XYWAV at one time
- You should remain in bed after taking each dose of XYWAV
In the clinical study, people with IH were able to follow a once- or twice-nightly dosing schedule. During the period of the clinical study that measured how well XYWAV worked, almost 8 out of 10 people (77%) were following a twice‑nightly dosing schedule.
It’s important to remember…
- Wait at least 2 hours after eating before taking XYWAV
- Prepared doses should be taken within 24 hours after mixing
- Store XYWAV in a safe place, away from children and pets
XYWAV Medication Guide and Instructions for Use
Read the Instructions for Use and the Medication Guide for detailed instructions on preparing and taking XYWAV.
See how Jennie manages her nighttime routine with XYWAV
"Once i got more confident with taking XYWAV, it became a routine. Things got a little bit better and better until I finally no longer needed as many naps during the day."
—Jennie, XYWAV Standup Champion
Real patient compensated for their time. Individual results may vary.
See how Jennie manages her nighttime routine with XYWAV
Personalized, 24/7 support through the myWAV app:
- Helps you get started on important steps
- Tracks your XYWAV shipments and important treatment calls in one place
- Organizes your daily schedule, insurance information, treatment tips and more
Get started today! It’s simple to put your smartphone to work.
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