Are you managing your nighttime and daytime symptoms of IH?

Woman lying in bed under covers and sleeping

IH can include:

Feeling very sleepy during the day despite getting plenty of rest.

Severe grogginess or confusion when waking up regardless of how much sleep you get or how many alarms you set.

Defined as severe grogginess or confusion when waking up
Can include feeling disoriented, irritable, or even clumsy
May last 30 minutes to a few hours in the morning or after a nap

Difficulty focusing, trouble thinking clearly, or memory problems due to excessive daytime sleepiness—often described as “brain fog.”

Ability to sleep for many hours of the day—sometimes for 11 hours or more.

Not feeling refreshed or better after napping (may even feel worse).

Not feeling rested when you wake up, despite sleeping a typical (or more than typical) amount each night

See where your daytime sleepiness falls on the Epworth Sleepiness Scale (ESS) and share your results with your doctor

Find out how IH may be affecting more of your day

Many people share similar experiences managing their IH. See which of these sound familiar to you by reviewing the cards.

Excessive daytime sleepiness is the only symptom of IH

That's correct Let's take a closer look

IH is a 24-hour condition with daytime and nighttime symptoms, including excessive daytime sleepiness, sleep inertia, (severe grogginess or confusion when waking up), cognitive impairment (brain fog), long sleep time, and unrefreshing sleep.

Feeling extremely groggy while trying to wake up after sleep is no different than daytime sleepiness

That's correct Let's take a closer look

The severe and lasting grogginess and confusion you feel when you try to wake up could be sleep inertia, a symptom of IH that can make it feel impossible to get out of bed.

If you have IH, getting more sleep will make you feel fully rested and energized throughout the day

That's correct Did you know?

With IH, no matter how much you sleep, it’s often not refreshing. Similar to sleep at night, daytime naps may also be long (often >1 hour) and unrefreshing.

There is no FDA-approved medication to treat IH

That's correct Here's what to know

Low-sodium* XYWAV is the first and only FDA-approved medication to treat IH in adults. XYWAV has been studied across both daytime and nighttime symptoms of IH, including excessive daytime sleepiness, sleep inertia, cognitive impairment, and long sleep time.

*XYWAV contains 131 mg of sodium at the 9-g nightly dose.

How are the symptoms of IH affecting you?

Take a short quiz to evaluate how the nighttime and daytime symptoms of IH may be affecting you.

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People with IH may be at risk for cardiovascular conditions

Cardiovascular conditions have been found to occur more often in people with IH.

One study found that compared to people without IH, people with IH had:

the risk of

HIGH BLOOD
PRESSURE^*†

the risk of a

MAJOR ADVERSE
CARDIOVASCULAR
EVENT (MACE)^*†‡

Managing sodium intake matters

Limiting sodium intake can help reduce the risk for cardiovascular disease. XYWAV contributes less than 10% of the American Heart Association's daily recommended limit at the maximum nightly dose.

*Based on an analysis of 11,951 people with IH and 59,755 people without IH. Groups were balanced on characteristics including age, sex, race/ethnicity, geographic region, and payer type. People with IH had at least 12 months of continuous health insurance before and after their first diagnosis. People without IH had at least 12 months of continuous health insurance before and after a randomly selected date within at least 4 years of continuous plan eligibility. Based on data from 2016–2024.

^†Hazard ratio.

^‡MACE: heart failure, stroke, myocardial infarction, unstable angina, or coronary revascularization procedures.

Watch Diana and Dr Meskill discuss her daytime and nighttime IH symptoms

"I don’t have room to lose focus or have a day to struggle thinking. From the time I wake up there’s a countdown to sleep."
—Diana, XYWAV Standup Champion
Real patient compensated for their time. Individual results may vary.

Watch Diana and Dr Meskill discuss her daytime and nighttime IH symptoms

Diana, a XYWAV patient with Idiopathic Hypersomnia, discusses her experience with Idiopathic Hypersomnia

Find out how the nighttime and daytime symptoms of IH may be affecting you

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XYWAV (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

the following symptoms in people 7 years of age or older with narcolepsy:
- sudden onset of weak or paralyzed muscles (cataplexy)
- excessive daytime sleepiness (EDS)
idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.