Are you managing your narcolepsy symptoms of cataplexy and/or excessive daytime sleepiness?

Woman sleeping on a tan couch with a yellow blanket and a brown pillow

Symptoms of narcolepsy

Defined as the uncontrollable need to sleep during the day. People with narcolepsy type 1 and people with narcolepsy type 2 experience EDS.

A brief loss of muscle control that can happen when you feel a strong emotion. People with narcolepsy type 1 experience cataplexy.

The impact of narcolepsy

It's important to talk to your doctor about your symptoms of cataplexy or EDS, even if you are already on treatment. Continuing to assess your symptoms can help your doctor adjust your management plan as needed.

See where your daytime sleepiness falls on the Epworth Sleepiness Scale (ESS) and share your results with your doctor

See how excessive daytime sleepiness and cataplexy impacted Grace

Watch to see how Grace manages 2 key daytime symptoms of narcolepsy.

“I have narcolepsy type 1, and I take XYWAV to help treat my excessive daytime sleepiness and cataplexy.”
—Grace, XYWAV Standup Champion
Real patient compensated for their time. Individual results may vary.

See how excessive daytime sleepiness and cataplexy impacted Grace

Watch to see how Grace manages 2 key daytime symptoms of narcolepsy.

Grace, a XYWAV patient with narcolepsy, shares her experience with excessive daytime sleepiness and cataplexy

People with narcolepsy may be at risk for cardiovascular conditions

Cardiovascular conditions have been found to occur more often in people with narcolepsy.

One study found that compared to people without narcolepsy, people with narcolepsy had:

the risk^* of

HIGH BLOOD
PRESSURE^†

the risk^* of

HEART
ATTACK^‡

the risk^§ of

STROKE^‖

*Odds ratio.
^†Based on an interview study of 320 people with narcolepsy compared to 1464 people without narcolepsy matched for age, sex, and body mass index.
^‡Based on an analysis of 9312 people with narcolepsy and 46,559 people without narcolepsy matched by age, sex, geographic region, and payer who had continuous insurance coverage between the years of 2006 and 2010.
^§Hazard ratio.
^‖Based on an analysis of 34,562 people with narcolepsy and 100,405 people without narcolepsy matched by presence of relevant health conditions, including sleep apnea and diabetes.

Managing sodium intake matters

Consuming too much sodium is a risk factor for cardiovascular disease. A study determined that each 1000-mg increase in daily sodium levels was associated with an 18% increased risk of cardiovascular disease.

For each 1000 mg of sodium per day = 18% higher risk.

*Study Design: Researchers combined data from 6 studies involving a total of 10,709 people to see how sodium intake affects cardiovascular risk. Participants provided multiple 24-hour urine samples, the most accurate way to measure sodium intake. The main outcome was whether participants experienced any major heart or blood vessel events, such as heart procedures, heart attacks, or strokes, within approximately 8 to 11 years since the studies began.

Other factors may also increase the risk of cardiovascular conditions

You may be able to address your risk factors for cardiovascular disease through lifestyle changes, including:

Smoking

Physical activity

Diet

Body weight

Find out how the symptoms of narcolepsy may be affecting you

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XYWAV (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

the following symptoms in people 7 years of age or older with narcolepsy:
- sudden onset of weak or paralyzed muscles (cataplexy)
- excessive daytime sleepiness (EDS)
idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.