What is XYWAV?

XYWAV is the first and only low-sodium* oxybate treatment for excessive daytime sleepiness (EDS) and/or cataplexy in narcolepsy patients 7 years of age and older.

*XYWAV contains 131 mg of sodium at the maximum recommended nightly dose.

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XYWAV helps manage 2 key symptoms of narcolepsy

Excessive daytime sleepiness

Cataplexy

Unlike stimulants and wake-promoting agents that are taken during the day, XYWAV is different—it’s taken at night^†
XYWAV can also be taken in addition to daytime medications like stimulants

^†The exact way XYWAV works for the treatment of EDS and cataplexy in patients with narcolepsy is unknown.

Your sodium intake matters

XYWAV is the only low-sodium oxybate, making it the cardiovascular-conscious choice based on its reduced sodium content. XYWAV has ~1509 mg less sodium per maximum recommended nightly dose than high-sodium oxybates.

A 9g nightly dose of XYWAV has ~1300 mg less sodium than the ideal 1500mg sodium intake limit for most adults and the sodium content of an order of four large french fries or high-oxybates

A 9g nightly dose of XYWAV has ~1200 mg less sodium than the ideal 1500mg sodium intake limit for most adults and ~1300 mg less sodium than the sodium content of an order of four large french fries or high-sodium oxybates

*XYREM^® (sodium oxybate) oral solution and LUMRYZ™ (sodium oxybate) contain ~1640 mg of sodium at the maximum recommended 9-g nightly dose.
^†Based on an average of 380 mg of sodium in 1 large serving of french fries according to a 2012 USDA analysis of 3 fast-food chains.

The sodium content in XYWAV vs XYREM

Because XYWAV has significantly less sodium compared to XYREM, choosing XYWAV over XYREM can help reduce chronic sodium burden, a risk factor for developing cardiovascular disease.

Learn about Jake's experience with XYWAV

Wondering if an oxybate treatment like XYWAV may be right for you? See how XYWAV had an impact on Jake.

"I have been taking XYWAV for about a year and a half now. XYWAV helps treat my EDS and cataplexy."
—Jake, XYWAV Standup Champion
Real patient compensated for their time. Individual results may vary.

Learn about Jake's experience with XYWAV

Wondering if an oxybate treatment like XYWAV may be right for you? See how XYWAV had an impact on Jake.

Jake, a XYWAV patient with narcolepsy, shares his experience with XYWAV

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Find out how XYWAV was studied

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XYWAV (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

the following symptoms in people 7 years of age or older with narcolepsy:
- sudden onset of weak or paralyzed muscles (cataplexy)
- excessive daytime sleepiness (EDS)
idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.