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Idiopathic Hypersomnia (IH) is more than feeling tired during the day

Ask your doctor about XYWAV, the only FDA-approved treatment studied across multiple symptoms for adults with IH.

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Unlike stimulants and wake-promoting agents that are taken during the day, XYWAV is different—it's taken at night to help treat multiple symptoms of Idiopathic Hypersomnia, such as excessive daytime sleepiness, sleep inertia (severe grogginess or confusion when waking up), long sleep time, and cognitive impairment.

What are the symptoms of Idiopathic Hypersomnia?

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Excessive daytime sleepiness may be most common but experiencing severe and prolonged difficulty waking up (also known as sleep inertia) or not feeling refreshed after a nap could be symptoms of Idiopathic Hypersomnia.

Know your symptoms

How do I talk with my doctor about XYWAV?

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Take this quiz to see how Idiopathic Hypersomnia impacts you, like needing to set multiple alarms or finding it hard to concentrate.

How is XYWAV taken?

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XYWAV offers individualized dosing options. It's most often taken twice nightly, but it can also be taken once nightly.

Patient Diana sharing her XYWAV® story

My life used to be consumed by sleep, but taking XYWAV twice nightly helps me fight daytime sleepiness. I wake up each morning with less sleep inertia and don't need to nap as much during the day.”


XYWAV IH Ambassador

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Real patient compensated for their time. Individual results may vary.

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We're here to support you with information on Idiopathic Hypersomnia, starting XYWAV, tips for talking with your doctor, JazzCares®, and more. Join our email list today.


JazzCares is here to help

See if you're eligible for one of the XYWAV cost savings programs. You could pay as little as $5 a month for XYWAV.*†‡§

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*For patients with commercial insurance (HMO, PPO, employer-sponsored, etc.)

Subject to a maximum annual benefit.

You must be a resident of the US, Puerto Rico, or other US territory.

§You must be enrolled in the XYWAV and XYREM REMS.

Jazz Pharmaceuticals reserves the right to terminate or modify this program at any time with or without notice. Other Terms and Conditions apply.

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Patient Jennie treatment story video

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Jennie, a real patient and XYWAV IH Ambassador, shares her treatment story.

Ready to get started? XYWAV offers support at every step of the way—from personal mentors to tracking tools in the myWAV app.

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XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

  • the following symptoms in people 7 years of age or older with narcolepsy:
    • sudden onset of weak or paralyzed muscles (cataplexy)
    • excessive daytime sleepiness (EDS)
  • idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

  • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
  • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
  • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

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