Skip Main Links
Prescribing InformationMedication Guide
Important Safety Information
For Healthcare
Unlock more
XYWAV® logo


Get access to support and cost savings with JazzCares for XYWAV

If you are prescribed XYWAV, JazzCares for XYWAV is here to help support you throughout your treatment journey. Watch Cyndy, a JazzCares Nurse Case Manager, explain the offerings that can help support you while you are taking XYWAV in the video below.

Call the Certified Pharmacy at 1-866-997-3688 for more information.

Commercially insured patients can pay as little as $5*†‡§

From insurance coverage to getting refill reminders to treatment questions, JazzCares® is designed to give you the support and assistance you need, right from the start. No matter where you are in your treatment journey, JazzCares is there—and just a call away.

Starting on XYWAV:

The XYWAV Coupon Program*

Pay as little as $5 for XYWAV through the Coupon Program. Want to find out if you are eligible? JazzCares is here to help.†‡§

The XYWAV Quick Start Voucher*

Are you waiting for your insurance to cover XYWAV? You may be eligible to receive a free 1-month supply of XYWAV with the Quick Start Voucher.‡§

Staying on XYWAV:

The XYWAV Bridge Program*

Life changes quickly. JazzCares will do everything we can to avoid any treatment interruption because of it. The Bridge Program can provide eligible patients up to 4 months of XYWAV for free.‡§

The XYWAV Patient Assistance Program

If you are uninsured or your insurance does not cover XYWAV, you may be eligible to receive treatment for free.§

  • *For patients with commercial insurance (HMO, PPO, employer-sponsored, etc.).
  • Subject to a maximum annual benefit.
  • You must be a resident of the US, Puerto Rico, or other US territory.
  • §You must be enrolled in the XYWAV and XYREM REMS.

Jazz Pharmaceuticals reserves the right to terminate or modify this program at any time with or without notice.
Other Terms and Conditions apply.

Call the Certified Pharmacy at 1-866-997-3688 for more information.

Watch video: Watch a JazzCares® Nurse Case Manager walk you through all JazzCares has to offer

Watch a JazzCares® Nurse Case Manager walk you through all JazzCares has to offer

Learn about enrolling in JazzCares® once you are prescribed XYWAV. You'll access a range of support services, including financial support programs, personalized resources, as well as nursing and pharmacy support.

XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

  • the following symptoms in people 7 years of age or older with narcolepsy:
    • sudden onset of weak or paralyzed muscles (cataplexy)
    • excessive daytime sleepiness (EDS)
  • idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

  • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
  • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
  • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

Up Arrow Icon
Jazz Pharmaceuticals homepage
Unlock more support

This site is intended for U.S. residents ages 18 and older.

© 2023 Jazz Pharmaceuticals plc or its subsidiaries US-XYW-2200416 Rev1123