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XYWAV® Narcolepsy Homepage
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What is Xywav

XYWAV is for people 7 years of age or older with cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy

Comorbidity riskComorbidity risk

Did you know that people with narcolepsy are at an increased risk of certain cardiovascular conditions?

A study has shown that people with narcolepsy were at a 2.5x higher risk* to have a stroke and 1.6x higher risk* to have a heart attack than people without narcolepsy.

Some risk factors for cardiovascular disease are modifiable, such as excessive sodium intake. Fortunately, for most adults, reducing sodium intake by 1000 mg per day can help reduce the risk for high blood pressure, heart disease, and stroke.

  • *Odds ratio.
  • A retrospective analysis of US medical claims data for 9312 people with narcolepsy and a control group of 46,559 without narcolepsy.

XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat the following symptoms in people 7 years of age or older with narcolepsy: Sudden onset of weak or paralyzed muscles (cataplexy) and excessive daytime sleepiness (EDS)

Discover a lower-sodium oxybate choice

XYWAV is the first and only lower-sodium oxybate treatment approved by the FDA for treating cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy. XYWAV has 92% less sodium than XYREM® (sodium oxybate) oral solution. At the maximum recommended 9 g nightly dose, XYWAV contains 131 mg of sodium per night. That's ~1509 mg of sodium less than XYREM's ~1640 mg.

Sodium content & XYWAV

XYWAV is thought to work during sleep to help with symptoms of cataplexy and EDS during the day*

*The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

The XYWAV Coupon Program

Did you know over 99% of commercially insured patients have a XYWAV co-pay of $5 or less. JazzCares® can connect you with the Coupon Program where you too can pay as little as $5, if eligible.†‡§

Plus, JazzCares can help support your doctor's office in navigating your specific insurance requirements to help get you the treatment you need.

Subject to a maximum monthly benefit.

You must be a resident of the US, Puerto Rico, or other US territory.

§You must be enrolled in the XYWAV and XYREM REMS.

Jazz Pharmaceuticals reserves the right to terminate or modify this program at any time with or without notice. Other Terms and Conditions apply.

Financial support, based on your personal needs

Jazz Pharmaceuticals is here to help you find programs that may help you reduce the cost of XYWAV.

Show me how to save

Standup championscan educate and inspire

Standup Champions are people who take XYWAV and want to share their experiences to help and inspire others. Watch Oscar's videos to follow him through a typical day and learn how he fits XYWAV treatment into his life.

Why you should talk to your doctor about XYWAV today

XYWAV is thought to work during sleep to help with symptoms of cataplexy and EDS during the day.

The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

XYWAV has 92% less sodium than XYREM oral solution. At the maximum recommended 9 g nightly dose, XYWAV contains 131 mg of sodium per night. That's ~1509 mg of sodium less than XYREM's ~1640 mg.

Choosing XYWAV over XYREM can help reduce sodium intake, a modifiable risk factor for cardiovascular disease.*

*XYWAV and XYREM have never been directly compared to each other in a clinical study.

XYWAV is the first and only lower-sodium** oxybate approved by the FDA for treating cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy.

**compared to XYREM.

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XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

  • the following symptoms in people 7 years of age or older with narcolepsy:
    • sudden onset of weak or paralyzed muscles (cataplexy)
    • excessive daytime sleepiness (EDS)
  • idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

  • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
  • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
  • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

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