NARCOLEPSY
LYING DOWN
XYWAV is for people 7 years of age or older with cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy
Did you know that people with narcolepsy are at an increased risk of certain cardiovascular conditions?
A study has shown that people with narcolepsy were at a 2.5x higher risk* to have a stroke and 1.6x higher risk* to have a heart attack than people without narcolepsy.†
Some risk factors for cardiovascular disease are modifiable, such as excessive sodium intake. Fortunately, for most adults, reducing sodium intake by 1000 mg per day can help reduce the risk for high blood pressure, heart disease, and stroke.
- *Odds ratio.
- †A retrospective analysis of US medical claims data for 9312 people with narcolepsy and a control group of 46,559 without narcolepsy.
XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat the following symptoms in people 7 years of age or older with narcolepsy: Sudden onset of weak or paralyzed muscles (cataplexy) and excessive daytime sleepiness (EDS)
Discover a lower-sodium oxybate choice
XYWAV is the first and only lower-sodium oxybate treatment approved by the FDA for treating cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy. XYWAV has 92% less sodium than XYREM® (sodium oxybate) oral solution. At the maximum recommended 9 g nightly dose, XYWAV contains 131 mg of sodium per night. That's ~1509 mg of sodium less than XYREM's ~1640 mg.
XYWAV is thought to work during sleep to help with symptoms of cataplexy and EDS during the day*
*The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

The XYWAV Coupon Program
Did you know over 99% of commercially insured patients have a XYWAV co-pay of $5 or less. JazzCares® can connect you with the Coupon Program where you too can pay as little as $5, if eligible.†‡§
Plus, JazzCares can help support your doctor's office in navigating your specific insurance requirements to help get you the treatment you need.
†Subject to a maximum monthly benefit.
‡You must be a resident of the US, Puerto Rico, or other US territory.
§You must be enrolled in the XYWAV and XYREM REMS.
Jazz Pharmaceuticals reserves the right to terminate or modify this program at any time with or without notice. Other Terms and Conditions apply.
Financial support, based on your personal needs
Jazz Pharmaceuticals is here to help you find programs that may help you reduce the cost of XYWAV.
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can educate and inspire
Standup Champions are people who take XYWAV and want to share their experiences to help and inspire others. Watch Oscar's videos to follow him through a typical day and learn how he fits XYWAV treatment into his life.

Why you should talk to your doctor about XYWAV today
XYWAV is thought to work during sleep to help with symptoms of cataplexy and EDS during the day.‖
‖The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.
XYWAV has 92% less sodium than XYREM oral solution. At the maximum recommended 9 g nightly dose, XYWAV contains 131 mg of sodium per night. That's ~1509 mg of sodium less than XYREM's ~1640 mg.
Choosing XYWAV over XYREM can help reduce sodium intake, a modifiable risk factor for cardiovascular disease.*
*XYWAV and XYREM have never been directly compared to each other in a clinical study.
XYWAV is the first and only lower-sodium** oxybate approved by the FDA for treating cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy.
**compared to XYREM.
myWAV: Online and at your fingertips
Connect to educational resources and support. You'll find answers to some of your questions, personalized encouragement, useful tips, and an app to help you get started and offer you support once your doctor has prescribed XYWAV.