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XYWAV® Narcolepsy Homepage


XYWAV is the first and only
low‑sodium oxybate*

*XYWAV contains 131 mg of sodium at the maximum recommended nightly dose.

Patient speaking to a doctor with an elephant (made of salt) in the room

If you’re considering an oxybate—either with stimulants or on its own—talk to your doctor about the high-sodium elephant in the room. Ask about XYWAV, the only low-sodium option.

XYWAV has ~1509 mg less sodium per maximum recommended nightly dose than high-sodium oxybates

  • High-sodium oxybates, such as XYREM® (sodium oxybate) oral solution and LUMRYZ (sodium oxybate) for extended-release oral suspension, contain ~1640 mg of sodium per day at the maximum 9-g nightly dose. That's more sodium than 4 orders of large french fries
  • High-sodium oxybates contain ~109% of the American Heart Association's ideal total daily sodium intake for most adults of 1500 mg
    • At the maximum recommended nightly dose of a high-sodium oxybate, such as XYREM or LUMRYZ, you can ingest more sodium than the American Heart Association recommends for an entire day before you eat or drink anything

Because XYWAV has 92% less sodium than high‑sodium oxybates, choosing XYWAV can help reduce sodium intake, a modifiable risk factor for cardiovascular disease.

Scroll to view chart

Bar graph comparing the sodium content of 9-g dose of XYREM/LUMRYZ (~1640 mg), 9-g dose of XYWAV (131 mg), and 4 large orders of fries (~1520 mg).

Based on an average of 380 mg of sodium in 1 large serving of french fries according to a 2012 USDA analysis of 3 fast-food chains.

HHS/USDA = US Department of Health and Human Services and US Department of Agriculture; AHA = American Heart Association.

§For people ages ≥14 years.

Transitioning from XYREM

Because XYWAV has significantly less sodium compared to high‑sodium oxybates, choosing XYWAV can help reduce excessive sodium intake, a modifiable risk factor for developing cardiovascular disease

The FDA has determined XYWAV to be clinically superior to XYREM oral solution, indicating in their summary that:

  • XYWAV is clinically superior to XYREM by means of greater safety because XYWAV contains significantly less sodium than XYREM
  • The differences in sodium content between XYWAV and XYREM at recommended doses will be clinically meaningful in reducing cardiovascular diseases for many people with narcolepsy who suffer from cataplexy and/or EDS

High-sodium oxybates, including XYREM and LUMRYZ, have ~1640 mg of sodium in a 9-g dose.

  • A clinical trial comparing the efficacy and safety of XYWAV and LUMRYZ has not been conducted

Choosing XYWAV over high‑sodium oxybates, including the once‑nightly high‑sodium oxybate, reduces chronic sodium burden, which makes it the safer option.

The decision of the FDA Office of Orphan Product Development (OOPD) is based on findings that XYWAV provides a greatly reduced chronic sodium burden compared to XYREM. There are no head-to-head data for XYWAV and XYREM.

I'm very health-conscious, so I was excited when I learned that a lower-sodium oxybate treatment was available.”


Diagnosed with narcolepsy type 1.

Compensated for his time. Results may vary.

Talk to your doctor about XYWAV today. Download the Doctor Discussion Guide to help prepare you for the discussion.

Remember to take it with you to your next visit!

Download the guide

XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

  • the following symptoms in people 7 years of age or older with narcolepsy:
    • sudden onset of weak or paralyzed muscles (cataplexy)
    • excessive daytime sleepiness (EDS)
  • idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

  • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
  • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
  • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

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