XYREM and XYWAV
XYWAV is the first and only
Whether you're currently taking XYREM® (sodium oxybate) oral solution, a high-sodium oxybate, or taking a stimulant and considering adding an oxybate, talk to your doctor about the high-sodium elephant in the room
The FDA has released important findings about XYWAV
XYWAV is clinically superior* to XYREM in cardiovascular safety due to its significantly lower sodium content.
The differences in sodium content between XYWAV and XYREM at recommended doses will be clinically meaningful in reducing cardiovascular diseases in many people with narcolepsy who suffer from excessive daytime sleepiness (EDS) and/or cataplexy.
* The decision of the FDA Office of Orphan Product Development (OOPD) is based on findings that XYWAV provides a greatly reduced chronic sodium burden compared to XYREM. There are no
Choosing XYWAV over XYREM could help reduce your sodium intake, a modifiable risk factor for cardiovascular disease†
Because XYWAV has 92% less sodium than XYREM, a high-sodium oxybate, choosing XYWAV can help reduce sodium intake, a modifiable risk factor for cardiovascular disease.
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†XYWAV and XYREM have never been directly compared to each other in a clinical study.
‡Based on an average of 380 mg sodium in 1 large serving of French fries (~1520 mg for 4 servings) according to a 2012 USDA analysis of 3 fast food chains.
§For people ages ≥14 years.
AHA, American Heart Association; HHS, US Department of Health and Human Services; USDA, US Department of Agriculture.
Same active ingredient.
- Both XYWAV and XYREM contain oxybate (0.413 g/mL of oxybate)
- XYWAV contains 92% less sodium than XYREM
- The lower-sodium formulation required adding minerals that are not found in XYREM. This is why XYWAV will taste different than XYREM
I'm very health-conscious, so I was excited when I learned that a
lower-sodium oxybate treatment was available.”
Diagnosed with narcolepsy type 1.
Talk to your doctor about XYWAV today. Download the Doctor Discussion Guide to help prepare you for the discussion.
Remember to take it with you to your next visit!Download the guide