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XYWAV® Narcolepsy Homepage

XYREM and XYWAV

XYWAV is the first and only lower‑sodium oxybate

The FDA has released important findings about XYWAV

XYWAV is clinically superior* to XYREM® (sodium oxybate) oral solution in cardiovascular safety due to its significantly lower sodium content.

The differences in sodium content between XYWAV and XYREM at recommended doses will be clinically meaningful in reducing cardiovascular diseases in many people with narcolepsy who suffer from excessive daytime sleepiness (EDS) and/or cataplexy.

*The decision of the FDA Office of Orphan Product Development (OOPD) is based on findings that XYWAV provides a greatly reduced chronic sodium burden compared to XYREM. There are no head-to-head data for XYWAV and XYREM.

Choosing XYWAV over XYREM could help reduce your sodium intake, a modifiable risk factor for cardiovascular disease

Because XYWAV has 92% less sodium than XYREM, a high-sodium oxybate, choosing XYWAV can help reduce sodium intake, a modifiable risk factor for cardiovascular disease.

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XYWAV (9g nightly) contains approximately 1509mg less sodium per day than XYREM (9g nightly)

XYWAV and XYREM have never been directly compared to each other in a clinical study.

Based on an average of 380 mg sodium in 1 large serving of French fries (~1520 mg for 4 servings) according to a 2012 USDA analysis of 3 fast food chains.

§For people ages ≥14 years.

AHA, American Heart Association; HHS, US Department of Health and Human Services; USDA, US Department of Agriculture.

Transitioning from XYREM

Same active ingredient.
Lower-sodium formulation.

  • Both XYWAV and XYREM contain oxybate (0.413 g/mL of oxybate)
  • XYWAV contains 92% less sodium than XYREM
  • The lower-sodium formulation required adding minerals that are not found in XYREM. This is why XYWAV will taste different than XYREM
XYWAV mineral content: calcium=687mg; magnesium=182 mg; potassium=642mg; sodium=131mg

I'm very health-conscious, so I was excited when I learned that a lower-sodium oxybate treatment was available.

Oscar

Diagnosed with narcolepsy type 1.

Watch Oscar's story

Download the Doctor Discussion Guide to help you be prepared to have an informed discussion about XYWAV at your next visit.

Download the Xywav doctor discussion guide

Your healthcare provider is the best source of information about XYWAV. The Doctor Discussion Guide gives you some useful information about the symptoms of cataplexy and EDS in people with narcolepsy and about XYWAV.

Download and take it with you to your next visit.

XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

  • the following symptoms in people 7 years of age or older with narcolepsy:
    • sudden onset of weak or paralyzed muscles (cataplexy)
    • excessive daytime sleepiness (EDS)
  • idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

  • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
  • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
  • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

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