XYWAV and SODIUM
XYWAV is the first and only
low‑sodium oxybate*
*XYWAV contains 131 mg of sodium at the maximum recommended nightly dose.

If you’re considering an oxybate—either with stimulants or on its own—talk to your doctor about the high-sodium elephant in the room. Ask about XYWAV, the only low-sodium option.
XYWAV has ~1509 mg less sodium per maximum recommended nightly dose than high-sodium oxybates
- High-sodium oxybates, such as XYREM® (sodium oxybate) oral solution and LUMRYZ™ (sodium oxybate) for extended-release oral suspension, contain ~1640 mg of sodium per day at the maximum 9-g nightly dose. That's more sodium than 4 orders of large french fries†
- High-sodium oxybates contain ~109% of the American Heart Association's ideal total daily sodium intake for most adults of 1500 mg
- At the maximum recommended nightly dose of a high-sodium oxybate, such as XYREM or LUMRYZ, you can ingest more sodium than the American Heart Association recommends for an entire day before you eat or drink anything
Because XYWAV has 92% less sodium than high‑sodium oxybates, choosing XYWAV can help reduce sodium intake, a modifiable risk factor for cardiovascular disease.
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†Based on an average of 380 mg of sodium in 1 large serving of french fries according to a 2012 USDA analysis of 3 fast-food chains.
‡HHS/USDA = US Department of Health and Human Services and US Department of Agriculture; AHA = American Heart Association.
§For people ages ≥14 years.
Because XYWAV has significantly less sodium compared to high‑sodium oxybates, choosing XYWAV can help reduce excessive sodium intake, a modifiable risk factor for developing cardiovascular disease
The FDA has determined XYWAV to be clinically superior‖ to XYREM oral solution, indicating in their summary that:
- XYWAV is clinically superior to XYREM by means of greater safety because XYWAV contains significantly less sodium than XYREM
- The differences in sodium content between XYWAV and XYREM at recommended doses will be clinically meaningful in reducing cardiovascular diseases for many people with narcolepsy who suffer from cataplexy and/or EDS
High-sodium oxybates, including XYREM and LUMRYZ, have ~1640 mg of sodium in a 9-g dose.
- A clinical trial comparing the efficacy and safety of XYWAV and LUMRYZ has not been conducted
Choosing XYWAV over high‑sodium oxybates, including the once‑nightly high‑sodium oxybate, reduces chronic sodium burden, which makes it the safer option.
‖The decision of the FDA Office of Orphan Product Development (OOPD) is based on findings that XYWAV provides a greatly reduced chronic sodium burden compared to XYREM. There are no head-to-head data for XYWAV and XYREM.

I'm very health-conscious, so I was excited when I learned that a lower-sodium oxybate treatment was available.”
Oscar
Diagnosed with narcolepsy type 1.
Compensated for his time. Results may vary.
Talk to your doctor about XYWAV today. Download the Doctor Discussion Guide to help prepare you for the discussion.
Remember to take it with you to your next visit!
Download the guide