Transitioning from XYREM
Your doctor can transition you from
XYREM® (sodium oxybate) oral solution
to low‑sodium oxybate, XYWAV

Ready to address the high‑sodium elephant in the room?
It may be time to ask your doctor about XYWAV. At the maximum recommended 9 g nightly dose, XYWAV has 131 mg of sodium vs ~1640 mg with XYREM, a high-sodium oxybate. This means that XYWAV has 92% (~1509 mg) less sodium than XYREM.
Taking XYREM?
Interested in lowering your daily sodium intake?
Talk to your doctor about XYWAV.
If your doctor decides it's appropriate to transition you to XYWAV:
Your doctor is recommended to initially prescribe XYWAV at the same dose and regimen as your XYREM treatment.
Take XYWAV exactly as your doctor instructs. If needed, your doctor may adjust your dosage or dosing routine.
Your doctor won't need to re-enroll you in XYWAV and XYREM REMS, since you're already enrolled.

When I transitioned from XYREM to XYWAV, my doctor just told me to start on the dose I was on... I basically just picked up where I left off.*”
Oscar
Diagnosed with narcolepsy type 1.
*After transitioning from XYREM to XYWAV some people may require changes to their dosage based on efficacy and tolerability.Watch Oscar and others share their stories to help educate and inspire people with narcolepsy.
Your doctor will likely:
- Adjust your dosage or dosing routine to meet your needs
- Decide how long you should wait between taking your 2 nightly doses (within a time frame of 2½ to 4 hours apart)
- Work with you to develop a management plan

Although the new XYWAV bottle is smaller than the XYREM bottle, both bottles contain the same amount of medicine: 180 mL. Also, because XYWAV contains calcium, magnesium, and potassium, it will taste different than XYREM.

I was on XYREM for a couple of years. And then I read about XYWAV and how it had a 92% reduction in sodium from XYREM. I was immediately intrigued, so I asked my doctor about transitioning to XYWAV.”
Brooke
Diagnosed with narcolepsy type 1.