What is XYWAV
XYWAV is the first and only low‑sodium* oxybate treatment for cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy
*XYWAV contains 131 mg of sodium at the maximum recommended nightly dose.
XYWAV is thought to work during sleep to help with symptoms of cataplexy and excessive daytime sleepiness (EDS) during the day†
†The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

When I learned about the low sodium content of XYWAV, I was immediately interested.”
Brooke
Diagnosed with narcolepsy type 1.
Real XYWAV patient compensated for her testimonial. Individual results may vary.

XYWAV helps treat 2 common symptoms of narcolepsy
XYWAV is approved by the FDA to treat cataplexy and/or EDS in people ages 7 years and older with narcolepsy. In a clinical study, adults who took XYWAV but then switched to a placebo had worse EDS and more cataplexy attacks.
Ask about XywavUnlike other medications taken during the day, XYWAV is taken at night
Why you should talk to your doctor about XYWAV today
XYWAV is thought to work during sleep to help with symptoms of cataplexy and EDS during the day.‡
- ‡The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.
XYWAV is a low-sodium oxybate treatment with 92% less sodium than higher-sodium oxybate, XYREM® (sodium oxybate) oral solution. That's as much as ~1509 mg less sodium per night.§
- §At the maximum recommended nightly dose.
Choosing XYWAV over XYREM, a high-sodium oxybate, means you can help treat your symptoms of cataplexy and/or EDS in narcolepsy while also reducing your cardiovascular risk from excessive sodium.
XYWAV is the first and only lower-sodium‖ oxybate approved by the FDA for treating cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy.
‖Compared to XYREM. XYWAV and XYREM have never been directly compared to each other in a clinical study.
Get the Discussion GuideWhy we developed XYWAV
Jazz Pharmaceuticals originally introduced XYREM® (sodium oxybate) oral solution in 2002, which is indicated for treating cataplexy and excessive daytime sleepiness (EDS) in people 7 years of age or older with narcolepsy. XYREM contains ~1640 mg of sodium per day at the maximum recommended nightly adult dosage
XYWAV, with 131 mg of sodium per maximum recommended total nightly dose for adults

Each 9 g dose of XYWAV contains the following mineral content:
Mineral | Mineral Content (mg) |
---|---|
Calcium | 687 |
Magnesium | 182 |
Potassium | 642 |
Sodium | 131 |
XYWAV also contains the inactive ingredients of sucralose and purified water.

Get valuable information about XYWAV from an expert in sleep medicine
Learn about narcolepsy and also XYWAV, which may help treat cataplexy and/or EDS in people with narcolepsy. Plus, learn about the sodium content of XYWAV and why that matters for people with narcolepsy.
Intro to Xywav