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XYWAV® Narcolepsy Homepage

What is XYWAV

XYWAV is the first and only low‑sodium* oxybate treatment for cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy

*XYWAV contains 131 mg of sodium at the maximum recommended nightly dose.

XYWAV is thought to work during sleep to help with symptoms of cataplexy and excessive daytime sleepiness (EDS) during the day

The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

When I learned about the low sodium content of XYWAV, I was immediately interested.”


Diagnosed with narcolepsy type 1.

Real XYWAV patient compensated for her testimonial. Individual results may vary.

watch brooke's story

XYWAV helps treat 2 common symptoms of narcolepsy

XYWAV is approved by the FDA to treat cataplexy and/or EDS in people ages 7 years and older with narcolepsy. In a clinical study, adults who took XYWAV but then switched to a placebo had worse EDS and more cataplexy attacks.

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Unlike other medications taken during the day, XYWAV is taken at night

Learn about dosing

Why you should talk to your doctor about XYWAV today

XYWAV is thought to work during sleep to help with symptoms of cataplexy and EDS during the day.

  • The exact way XYWAV works for the treatment of cataplexy and EDS in patients with narcolepsy is unknown.

XYWAV is a low-sodium oxybate treatment with 92% less sodium than higher-sodium oxybate, XYREM® (sodium oxybate) oral solution. That's as much as ~1509 mg less sodium per night.§

  • §At the maximum recommended nightly dose.

Choosing XYWAV over XYREM, a high-sodium oxybate, means you can help treat your symptoms of cataplexy and/or EDS in narcolepsy while also reducing your cardiovascular risk from excessive sodium.

XYWAV is the first and only lower-sodium oxybate approved by the FDA for treating cataplexy and/or excessive daytime sleepiness (EDS) in narcolepsy.

Compared to XYREM. XYWAV and XYREM have never been directly compared to each other in a clinical study.

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Why we developed XYWAV

Jazz Pharmaceuticals originally introduced XYREM® (sodium oxybate) oral solution in 2002, which is indicated for treating cataplexy and excessive daytime sleepiness (EDS) in people 7 years of age or older with narcolepsy. XYREM contains ~1640 mg of sodium per day at the maximum recommended nightly adult dosage (9 g/night).

XYWAV, with 131 mg of sodium per maximum recommended total nightly dose for adults (9 g/night), was developed to provide a lower-sodium oxybate treatment option.

XYWAV® bottle

Each 9 g dose of XYWAV contains the following mineral content:

MineralMineral Content (mg)

XYWAV also contains the inactive ingredients of sucralose and purified water.

Get valuable information about XYWAV from an expert in sleep medicine

Learn about narcolepsy and also XYWAV, which may help treat cataplexy and/or EDS in people with narcolepsy. Plus, learn about the sodium content of XYWAV and why that matters for people with narcolepsy.

Intro to Xywav

XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

  • the following symptoms in people 7 years of age or older with narcolepsy:
    • sudden onset of weak or paralyzed muscles (cataplexy)
    • excessive daytime sleepiness (EDS)
  • idiopathic hypersomnia (IH) in adults.

Important Safety Information

WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

XYWAV can cause serious side effects, including the following:

  • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
  • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
  • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

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