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Consider your overall health when managing your narcolepsy

Learning about narcolepsy

Since there is no cure for narcolepsy, long-term management for symptoms, such as excessive daytime sleepiness (EDS) and cataplexy, may be needed.

  • EDS is the uncontrollable need to sleep during the day. Everyone with narcolepsy has EDS
  • Cataplexy is a common symptom of narcolepsy and can be described as when your muscles suddenly become weak or go limp when you feel a strong emotion. About 70% of people with narcolepsy are believed to have cataplexy

A study has shown that certain medical conditions are more frequently observed among people with narcolepsy compared to the general population

In a study, people with narcolepsy and people without narcolepsy were interviewed regarding sleeping habits, health, medical conditions and medications, sleep disorders, and mental disorders. People with narcolepsy were more likely to report having other health conditions, including heart disease, high cholesterol, depression, and anxiety.

    Other factors may increase the risk of certain health conditions

    For example, some risk factors for cardiovascular disease are "modifiable." That means you may be able to address them through lifestyle changes. These changes include:

    Sodium intake is a modifiable risk factor

    * According to a survey by the Centers for Disease Control and Prevention, 89% of adults in the US aged 19 years and older consume more than the limit of 2300 mg of dietary sodium per day recommended by the US Department of Health and Human Services and US Department of Agriculture in the 2015-2020 Dietary Guidelines for Americans.

      While sodium typically comes from what you eat and drink, it can also come from certain medications.

      Watch Georgia share how she lives with narcolepsy

      Follow Georgia through a typical day as she explains how she manages narcolepsy and her treatment. Learn about Standup Champions and see other people’s stories as well!

      Talk to your doctor about all aspects of your health

      When creating a narcolepsy management plan with your doctor, be sure to discuss all aspects of your overall health. Tips include:

      Learn more

      XYWAV® (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat:

      • the following symptoms in people 7 years of age or older with narcolepsy:
        • sudden onset of weak or paralyzed muscles (cataplexy)
        • excessive daytime sleepiness (EDS)
      • idiopathic hypersomnia (IH) in adults.

      Important Safety Information

      WARNING: Taking XYWAV with other central nervous system (CNS) depressants such as medicines used to make you or your child fall asleep, including opioid analgesics, benzodiazepines, sedating antidepressants, antipsychotics, sedating anti-epileptic medicines, general anesthetics, muscle relaxants, alcohol, or street drugs, may cause serious medical problems, including trouble breathing (respiratory depression), low blood pressure (hypotension), changes in alertness (drowsiness), fainting (syncope), and death.

      The active ingredient of XYWAV is a form of gamma-hydroxybutyrate (GHB). Abuse or misuse of illegal GHB alone or with other drugs that cause changes in alertness (or consciousness) has caused serious side effects. These effects include seizures, trouble breathing (respiratory depression), changes in alertness (drowsiness), coma, and death. Call your doctor right away if you or your child has any of these serious side effects.

      Because of these risks, you have to go through the XYWAV and XYREM REMS to have your or your child's prescription for XYWAV filled.

      Do not take XYWAV if you take or your child takes other sleep medicines or sedatives (medicines that cause sleepiness), drinks alcohol, or has a rare problem called succinic semialdehyde dehydrogenase deficiency.

      Keep XYWAV in a safe place to prevent abuse and misuse. Selling or giving away XYWAV may harm others, and is against the law. Tell your doctor if you have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

      Anyone who takes XYWAV should not do anything that requires them to be fully awake or is dangerous, including driving a car, using heavy machinery, or flying an airplane, for at least 6 hours after taking XYWAV. Those activities should not be done until you know how XYWAV affects you or your child.

      XYWAV can cause serious side effects, including the following:

      • Breathing problems, including slower breathing, trouble breathing, and/or short periods of not breathing while sleeping (sleep apnea). People who already have breathing or lung problems have a higher chance of having breathing problems when they use XYWAV.
      • Mental health problems, including confusion, seeing or hearing things that are not real (hallucinations), unusual or disturbing thoughts (abnormal thinking), feeling anxious or upset, depression, thoughts of killing yourself or trying to kill yourself, increased tiredness, feelings of guilt or worthlessness, or difficulty concentrating. Tell your doctor if you or your child have or had depression or have tried to harm yourself or themselves. Call your doctor right away if you have or your child has symptoms of mental health problems or a change in weight or appetite.
      • Sleepwalking. XYWAV can cause sleepwalking, which can cause injuries. Call your doctor if this occurs.

      The most common side effects of XYWAV in adults include nausea, headache, dizziness, anxiety, insomnia, decreased appetite, excessive sweating (hyperhidrosis), vomiting, diarrhea, dry mouth, parasomnia (a sleep disorder that can include abnormal dreams, abnormal rapid eye movement (REM) sleep, sleep paralysis, sleep talking, sleep terror, sleep-related eating disorder, sleepwalking, and other abnormal sleep-related events), somnolence, fatigue, and tremor.

      The most common side effects of XYREM (which also contains oxybate like XYWAV) in children include nausea, bedwetting, vomiting, headache, weight decrease, decreased appetite, dizziness, and sleepwalking.

      XYWAV can cause physical dependence and craving for the medicine when it is not taken as directed. These are not all the possible side effects of XYWAV.

      You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

      Please see full Prescribing Information, including BOXED Warning, and Medication Guide.

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      ©2021 Jazz Pharmaceuticals plc or its subsidiaries US-XYW-2100151 Rev1121

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